antibodybased immunohistochemistry ihc data across normal tissues  (Human Protein Atlas)

Journal: Current Issues in Molecular Biology

Article Title: Dual-Faced Role of GDF6 in Cancer: Mechanistic Insights into Its Context-Dependent Regulation of Metastasis and Immune Evasion Across Human Malignancies

doi: 10.3390/cimb47040249

Figure Lengend Snippet: The expression of GDF6 in various human normal tissues and tumor tissues. ( A ) The mRNA expression of GDF6 in normal human tissues. ( B ) GDF6 expression in tumors and healthy tissues (TCGA database). Tumor types with significantly downregulated GDF6 expression ( C ) and those with significantly upregulated expression ( D ) in the TCGA + GTEx databases. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Article Snippet: Normal tissue expression data were sourced from the Human Protein Atlas (HPA; https://www.proteinatlas.org , accessed on 15 February 2025).

Techniques: Expressing

Journal: bioRxiv

Article Title: Pan-cancer N -glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers

doi: 10.1101/2024.12.11.627962

Figure Lengend Snippet: (A &B) Contingency tables used to determine the likelihood of detecting a clinical (A) ADC and (B) CAR T target in the PDX human tumor N -glycoproteome against all other surface proteins in the human proteome. P-values were calculated using a Fisher’s exact test. (C) Normal tissue toxicity scoring system. (D) Distribution of full body normal tissue abundance or detection frequency of PDX target candidates (purple) vs solid tumor clinical immunotherapy targets (grey) in Jiang et al., (left), Human Protein Atlas (middle) and GTEx RNA-seq data (right). (E) Distribution of normal brain tissue abundance or detection frequency of PDX target candidates (purple) vs solid tumor clinical immunotherapy targets (grey) in Tushaus et al., (left), Human Protein Atlas brain IHC data (middle) and Human Protein Atlas brain RNA-seq data (right). (F) Distribution of normal heart tissue abundance or detection frequency of PDX target candidates (purple) vs solid tumor clinical immunotherapy targets (grey) in Berg Luecke et al., (left) and Doll et al., (middle & right). (D-F) P-values from unpaired Mann-Whitney U tests.

Article Snippet: Normal tissue IHC data were downloaded from Human Protein Atlas (v.23.0) .

Techniques: Glycoproteomics, RNA Sequencing, MANN-WHITNEY

Journal: Cancer Reports

Article Title: A Four‐Gene Autophagy‐Related Prognostic Model Signature and Its Association With Immune Phenotype in Lung Squamous Cell Carcinoma

doi: 10.1002/cnr2.70000

Figure Lengend Snippet: Results of differentially expressed analysis on ARGs and enrichment analysis of DE‐ARGs. (A) A heatmap of 48 differentially expressed ARGs between 326 LUSC samples and 32 normal controls. Each line represents a DE‐ARG and each row means a sample. The expression levels of genes are displayed with colors in each cell (red for high and blue for low). (B) The volcano plot of differentially expressed ARGs between LUSC samples and normal controls. (C) The enriched significant KEGG signal pathways of DE‐ARGs. The color represents the statistical significance of the term. The length indicates the counts of enriched genes.

Article Snippet: Immunohistochemistry data of ARGs in normal lung tissue and LUSC tumor tissue from The Human Protein Atlas project are also included (Figure ).

Techniques: Expressing